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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Fam Cancer. 2019 Jul;18(3):331–342. doi: 10.1007/s10689-019-00128-6

Table 4:

Mutation burden of likely pathogenic variants in DNA repair candidate genes present in different colorectal cancer phenotypes and controls

Mutated
Alleles		 Reference
Alleles		 Mutation
Burden		 P-valuea
LLS 4 18 0,222
LS 1 7 0,143 ns
TCGA 9 585 0.015 0.0007
Controls 197 7,141 0,027 0.003

LLS, Lynch-like syndrome; LS, Lynch syndrome; TCGA: The Cancer Genome Atlas database.

a

Fisher exact test performed between LLS and each other group. ns: non-statistical