Table 2. Subject and sample characteristics of the neurosurgery study participants.
Sample tissues available for each individual varied. Details of analyzed samples are shown. Timing of when peripheral tissues were obtained are listed as “days”. Day 0 is indicative of samples taken the day of surgery, after surgery is completed. For brain samples analyzed, the time (in minutes) between administration of the synthetic glucocorticoid and when the second (post) brain sample was resected was recorded. Abbreviations. GC: glucocorticoid, FCD: focal cortical dysplasia.
| Day(s) after surgery for peripheral sample collection | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subject | Sex | Age | Saliva | Blood | Buccal | Brain region (pre) | Brain region (post) | GC duration (minutes) | Pathology report (pre) | Pathology report (post) |
| 101 | female | 50 | 638 | |||||||
| 102 | female | 46 | 309 | |||||||
| 103 | female | 31 | 362 | 2 | ||||||
| 104 | female | 51 | 263 | 0 | ||||||
| 105 | female | 28 | 222 | 0 | ||||||
| 106 | male | 61 | 2 | 0 | ||||||
| 107 | male | 43 | 198 | 0 | ||||||
| 108 | male | 40 | 241 | 0 | ||||||
| 109 | male | 7 | 23 | 0 | 23 | Occipital area | Occipital area | 180 | FCD type Ic and gliosis | Same as pre-GC sample |
| 110 | male | 17 | 3 | 0 | 3 | Inferior lateral temporal cortex | Inferior lateral temporal cortex | 38 | Evidence of cortical dysplasia, focal meningitis, and cortical injury consistent with electrode placement | Same as pre-GC sample |
| 111 | female | 14 | 3 | 0 | 3 | |||||
| 112 | male | 31 | 2 | 0 | 2 | |||||
| 113 | male | 36 | 2 | 0 | 2 | Temporal cortex | Temporal cortex | 100 | Moderate, patchy gliosis, and multiple superficial subacute microinfarcts with adjacent leptomeningeal chronic inflammation consistent with history of previous dural grid placement | Same as pre-GC sample |
| 114 | male | 30 | 3 | 0 | 3 | Lateral temporal cortex | Lateral temporal cortex | 130 | Patchy mild gliosis | Same as pre-GC sample |
| 115 | male | 24 | 2 | 0 | 2 | Lateral temporal cortex | Hippocampus | 90 | Mild neuronal heterotopia and mild patchy gliosis | Hippocampal sclerosis and moderate patchy gliosis |
| 116 | male | 34 | 2 | 0 | 2 | Lateral temporal cortex | Lateral temporal cortex | 130 | Patchy moderate gliosis and focal meningitis secondary to electrode placement | Same as pre-GC sample |
| 117 | female | 49 | 2 | 0 | 2 | Lateral temporal cortex | Inferior lateral temporal cortex | 100 | FCD type Ic and white matter gliosis | Subpial and white matter gliosis |
| 118 | male | 5 | 4 | 0 | 4 | |||||
| 119 | male | 38 | 2 | 0 | 2 | Lateral temporal cortex | Hippocampus | 64 | White matter and cortical gliosis and subacute infarct | Hippocampal sclerosis |
| 120 | male | 11 | 122 | 0 | 14 | Temporal operculum | Temporal operculum | 152 | Mild neuronal disorganization with white matter and cortical gliosis | Same as pre-GC sample |
| 121 | male | 5 | 4 | 0 | 4 | Temporal pole | Temporal pole | 32 | FCD | Same as pre-GC sample |