Table 5. Significance of top KEGG-defined pathways enriched for genes with CpGs differentially methylated after dexamethasone exposure in buccal samples from individuals who underwent tooth extraction.
N = number of genes in the pathway. DM = number of genes with differentially methylated CpGs within the associated pathway.
| Pathway | N | DM | p.val | fdr |
|---|---|---|---|---|
| Olfactory transduction | 406 | 50 | 3.50E-06 | 1.20E-03 |
| Pentose and glucuronate interconversions | 34 | 14 | 3.40E-05 | 4.30E-03 |
| Ascorbate and aldarate metabolism | 27 | 12 | 4.60E-05 | 4.30E-03 |
| Steroid hormone biosynthesis | 59 | 18 | 5.30E-05 | 4.30E-03 |
| Retinol metabolism | 66 | 15 | 2.00E-03 | 0.11 |
| Drug metabolism - cytochrome P450 | 69 | 15 | 2.00E-03 | 0.11 |
| Porphyrin and chlorophyll metabolism | 42 | 12 | 2.80E-03 | 0.13 |
| Axon guidance | 174 | 46 | 5.20E-03 | 0.2 |
| Chemical carcinogenesis | 82 | 16 | 5.60E-03 | 0.2 |
| Drug metabolism - other enzymes | 79 | 17 | 6.70E-03 | 0.22 |