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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Hypertension. 2019 May 13;74(1):83–94. doi: 10.1161/HYPERTENSIONAHA.119.12873

Figure 5. Renin lineage and aquaporin 2 expressing cells in non-diabetic and diabetic Ren1d-Cre;mT/mG mouse kidneys (A) and colocalization analysis (B, C).

Figure 5.

A: Kidney sections from Ren1d-Cre;mT/mG mice show the presence of GFP+ collecting duct epithelial cells. Immunofluorescence for AQP2 show colocalization with GFP+ collecting duct cells in both diabetic and non-diabetic Ren1d-Cre;mT/mG mice. B: Colocalization analysis of GFP+ cells and immunofluorescence for AQP2 cells using Pearson’s correlation coefficient shows no difference between kidneys of control and diabetic Ren1d-Cre;mT/mG mice. C: A large image analysis of the GFP and AQP2 colocalized area per total area shows no significant difference between kidneys of control and diabetic Ren1d-Cre;mT/mG mice. AQP2: aquaporin 2; STZ: streptozotocin-treated mice; n=5 in each group;