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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Hypertension. 2019 May 20;74(1):173–183. doi: 10.1161/HYPERTENSIONAHA.119.13101

Figure 1. Experimental Design and Preeclamptic Phenotypes in the Mother.

Figure 1.

A) Schematic of the experimental design. Heterozygous E-V290M sires were bred with NT dams infused with either SAL (vehicle) or AVP. Offspring could either be wild-type (NT) or E-V290M. B) Longitudinal timeline of the study. Phase I is the gestational phase (in number of days) and Phase II is the life of offspring (in weeks). C-D) Preeclamptic phenotypes in the mother. C) Systolic blood pressure (SBP) was measured using tail-cuff plethysmography in SAL and AVP infused pregnant mice until gestational day (GD) 15. Data are presented as mean±SEM and analyzed by two-way repeated measures ANOVA, *P<0.05 vs. SAL pregnant. D) Urinary protein levels expressed as mg/mL (left) or mg/day (right) measured at baseline (base) and after infusion (GD17) of SAL or AVP in pregnant mice (Before SAL, n=6; GD17 SAL, n=9; before AVP, n=7; GD 17 AVP, n=20). Data are presented as mean±SEM and analyzed by two-way ANOVA. *P<0.05 vs. baseline.