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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Hypertension. 2019 May 20;74(1):173–183. doi: 10.1161/HYPERTENSIONAHA.119.13101

Figure 2. Ang-II Sensitivity in Adult Offspring.

Figure 2.

A) Systolic blood pressure measured using tail-cuff plethysmography in Ang-II-treated adult male (left) and female (right) NT and E-V290M offspring born from SAL or AVP-infused pregnancies. B) Cumulative concentration response curves for ACh in carotid arteries from Ang-II-treated adult male (left) and female (right) NT and E-V290M offspring born from SAL or AVP-infused pregnancies. C) 4-parameter non-linear curve fitting was used to calculate EC50 and maximum responses for all relaxation curves. Baseline values were constrained to zero. All data are presented as mean±SEM analyzed by 2-way RM ANOVA with Tukey’s multiple comparison test. *P<0.05 vs E-V290M SAL, #P<0.05 vs NT AVP. D) Cumulative concentration response curves for SNP in carotid arteries from Ang-II-treated adult male (left) and female (right) NT and E-V290M offspring born from SAL or AVP-infused pregnancies. Data are presented as mean±SEM analyzed by two-way ANOVA with repeated measures.