Table 1.
Markers of the Microvasculature
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Name | Type | endothelial cells | pericytes | smooth muscle cells | Other |
PECAM/ CD31 | Surface136 | ✓137 | ✗138 | ✗139 | Platelets, T‐cells. leukocytes137 |
IB4 Lectin | Var.140, 141 | ✓46, 142 | ✓45 | ✓143 | Macrophages144, microglia46, monocytes145 |
Col‐IV | ECM40 | ✓146 | ✓147 | ✓148 | Fibroblasts149, MSCs150 |
Laminin | ECM151 | ✓152 | ✓152 | ✓152 | Fibroblasts153, epithelial cells154 |
CD34 | Surface136 | ✓155 | ✗156 | ✗157 | MSCs, HSCs, muscle satellite cells, fibrocytes158 |
VE‐cadherin | Surface138 | ✓138 | ✗159 | ✗160 | None161 |
EMCN | Surface162 | ✓163 | ✗164 | ✗164 | Putative hematopoietic progenitor cells165 |
vWf | Internal166 | ✓167 | ✗167 | ✗168 | Megakaryocytes166 |
aSMA | Internal169 | ✗169 | ✓170 | ✓171 | Fibroblasts172, perisinusoidal cells169 |
MYH11 | Internal173 | ✗173 | ✓174 | ✓175 | None174 |
NG2 | Surface176 | ✗176 | ✓157 | ✓156 | Microglia170, macrophages, oligodendrocyte porogenitors177 |
N‐Cadherin | Surface178 | ✓179 | ✓159 | ✓180 | MSCs181, fibroblasts159, osteoblasts159 |
Desmin | Internal182 | ✗168 | ✓183 | ✓156 | Interstitial cells, muscle satellite cells158 |
PDGFRβ | Surface184 | ✗185 | ✓156 | ✓156 | MSCs156, fibroblasts156 , some neurons156 |
Perf. PECAM | Surface186, 187 | Perf.186 | ✗138 | ✗138 | Platelets188, leukocytes158 |
Perf. Neuro‐Trace | Internal189 | ✗189 | Capillary186 | ✗189 | Other neuronal cells when fixed (brain)189 |
FITC | Passive42 | Perf.42 | ✗42 | ✗42 | None42 |
Tie2 | Surface190 | ✓64 | ✓* 64 | ✓* 64 | Monocytes, macrophages67, HSCs191 |
Dextran | Passive192 | Perf.192 | ✗192 | ✗192 | None193 |
VEGFR2, FLK‐1 | Surface194 | ✓194 | ✗139 | ✗139 | HSCs195, macrophages196, neurons197 |
VEGFR1, FLT‐1 | Surface198 | ✓198 | ✗199 | ✗199 | HSCs, macrophages196, neurons197 |
EC, endothelial cell, ECM, extracellular matrix; HSC, hematopoietic stem cell, MSC, mesenchymal stem cell, Perf., perfused; PC, pericyte, SMC, smooth muscle cell; Var., various. Labeling: yes (✓), no (✗).
Note: Table shows general trends, there are exceptions with specific tissues, species, and disease conditions. *See main text.