Figure 4.

Lack of decidualization defect in Aire-KO mice. (A, B) Ovariectomized mice (+/+, WT, n = 5; +/–, heterozygous, n = 3; –/–, KO, n = 3) were subjected to hormonal stimulation followed by surgical induction of decidualization. In all three groups, there was a highly significant increase in uterine horn weight in response to the decidualization stimulus, with no genotype × treatment interaction. **, P < 0.001, two-way ANOVA on log₁₀-transformed data. (C) mRNA expression for Aire in undecidualized uterus, decidualized uterus, and thymus. Data are expressed as fold difference in quantity relative to the undecidualized uterus samples.