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HFD-induced lipid metabolic rhythms define a critical time window for lipid-lowering therapies. Under HFD conditions, 24-hour lipid biosynthesis and breakdown rhythms become synchronized in murine livers. Peak activity of lipid biosynthesis around the day-night transition defines a critical window for lipid lowering statin therapies through PPARα agonism. BS, biosynthesis; HFD, high-fat diet; PPAR, peroxisome proliferated activated receptor.
