Table 2.
Univariate and multivariate analysis for risk factors of mortality in AL cardiac amyloidosis with heart failure.
| Univariate Hazard Ratio | P-Value | Multivariate Hazard Ratio | P-Value | |
|---|---|---|---|---|
| RWT | 4.40 (1.87–10.30) | <0.0001 | 6.70 (2.45–18.30) | <0.001 |
| NYHA Class | 2.91 (2.14–3.97) | <0.001 | 1.50 (1.02–2.2) | 0.04 |
| Log BNP | 1.93 (1.58–2.38) | <0.001 | 1.45 (1.15–1.81) | <0.01 |
| Age (years) | 1.04 (1.02–1.06 | <0.0001 | 1.04 (1.01–1.06) | <0.01 |
| CRP | 1.02 (1.00–1.03) | <0.01 | 1.02 (1.00–1.04) | 0.01 |
| Female Sex | 0.87 (0.60–1.26) | 0.47 | — | — |
| Atrial Fibrillation | 1.70 (1.14–2.52) | <0.01 | — | — |
| Systolic Blood Pressure | 0.99 (0.98–1.00) | 0.11 | — | — |
| Troponin I | 1.14 (0.95–1.35) | 0.16 | — | — |
| MDRD eGFR (mL/min/1.73 m2) | 0.99 (0.98–1.00) | 0.051 | — | — |
| LVEF (%) | 0.97 (0.95–0.99) | <0.0001 | — | — |
| IVS (mm) | 1.14 (1.05–1.23) | <0.001 | — | — |
| LV mass index (g/m2) | 0.99 (0.99–1.00) | 0.88 | — | — |
| dFLC | 1.0004 (1.0001–1.0007) | 0.0008 | — | — |
| QRS duration (ms) on EKG | 1.003 (0.99–1.01) | 0.44 | — | — |
NYHA, New York Heart Association; BNP, brain natriuretic peptide; CRP, C-reactive protein; MDRD eGFR, glomerular filtration rate by Modification of Diet in Renal Disease equation; LVEF; left ventricular ejection fraction; RWT, relative wall thickness; IVS, interventricular septum; dFLC, difference between involved and uninvolved light chains; EKG, electrocardiogram.