Fig. 1. rFGF1^ΔHBS exhibits reduced mitogenic activity in renal tissue compared to rFGF1^WT.

C57BL/6J mice after 3 weeks of chronic administration of rFGF1 ^WT (2 mg/kg body weight), rFGF1^ΔHBS (2 mg/kg body weight), or control vehicle. a Representative images of PCNA or Ki-67 immunohistochemical staining of renal tissues (left panel) and quantitation using ImageJ software (right panel). Scale bar, 50 μm. b Expression of PCNA and Ki-67 in renal tissue as measured by western blot analyses (left panel) and quantitation using ImageJ software (right panel). Data are presented as the mean ± SEM (n = 6). *p < 0.05, ***p < 0.001