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. 2019 Jun 12;10(6):460. doi: 10.1038/s41419-019-1700-4

Fig. 6. Inhibition of TRPV4 expression or activity suppresses colon cancer cell growth in vivo.

Fig. 6

a The effect of TRPV4 knockdown or HC-067047 on a xenograft model in vivo. The upper panel represents the xenograft tumors of mice (n = 6) that were injected with HCT-116 or SW620 cells stably transfected with scrambled-shRNA (shScramble) or TRPV4-shRNA (shTRPV4). The lower panel represents xenograft tumors of mice (n = 6) that were injected with HCT-116 or SW620 cells then treated with vehicle (0.1% DMSO) or HC-067047 (4 μΜ) every 2 days. b Representative images of IHC staining of Ki-67 in xenograft tumor tissue. c The tumor growth curve of the xenograft model. The tumor volumes were measured once every 2 days (HCT-116) or 3 days (SW620). d The average tumor weight (n = 6) was measured after the mice were harvested. All quantitative data shown represent the means ± SEM of six mice. #P < 0.001, versus the shScramble group or versus vehicle group