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. 2019 Jun 12;9:8561. doi: 10.1038/s41598-019-44639-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Human rA1M protects kidney function but no effect on cardiac hypertrophy. (a) Albumin/Creatinine ratio (ACR) analysis of urine from pregnant females showed an increase of ACR at late-gestation in the preeclamptic females, which was absent in the rA1M-treated group. Shown is the mean ACR normalised to Ctrl-buff values for each gestation period, and n = number of females analysed. (b) Gene expression levels for HO-1, CAT and SOD2, normalised to the HPRT-gene levels in kidney from PE-buff and PE-A1M females, demonstrating significant reduction of HO-1 and CAT expression (*p = 0.04; **p = 0.04) after rA1M-treatment. The line represents the median and n = number of females analysed. (c) Preeclamptic females showed increased heart weight compared to Ctrl-buff at 17.5 dpc (*p = 0.002), which could not be alleviated by rA1M treatment (PE-A1M vs Ctrl-buff; **p = 0.008). Control groups showed similar heart weight as non-pregnant females. The line represents the median and n = number of females analysed.