Table 2.
A total of 102 hub molecules were identified in ovarian cancer
| ID | Gene | Description | Location | Ratio (tumor/control) |
|---|---|---|---|---|
| P09110 | ACAA1 | Acetyl-CoA acyltransferase 1 | Cytoplasm | 2.70 |
| P42025 | ACTR1B | ARP1 actin–related protein 1 homolog B | Cytoplasm | 0.64 |
| P11766 | ADH5 | Alcohol dehydrogenase 5 (class III), chi polypeptide | Cytoplasm | 0.52 |
| P08913 | ADRA2A | Adrenoceptor alpha 2A | Plasma membrane | 0.37 |
| P00568 | AK1 | Adenylate kinase 1 | Cytoplasm | 0.61 |
| P02768 | ALB | Albumin | Extracellular space | 0.34 |
| P54886 | ALDH18A1 | Aldehyde dehydrogenase 18 family member A1 | Cytoplasm | 1.74 |
| P00352 | ALDH1A1 | Aldehyde dehydrogenase 1 family member A1 | Cytoplasm | 0.44 |
| O75891 | ALDH1L1 | Aldehyde dehydrogenase 1 family member L1 | Cytoplasm | 0.64 |
| Q9BXN1 | ASPN | Asporin | Extracellular space | 0.45 |
| O75531 | BANF1 | Barrier to autointegration factor 1 | Nucleus | 0.65 |
| Q9BUT1 | BDH2 | 3-Hydroxybutyrate dehydrogenase 2 | Cytoplasm | 0.51 |
| Q03692 | COL10A1 | Collagen type X alpha 1 chain | Extracellular space | 0.24 |
| Q05707 | COL14A1 | Collagen type XIV alpha 1 chain | Extracellular space | 0.47 |
| Q07092 | COL16A1 | Collagen type XVI alpha 1 chain | Extracellular space | 0.43 |
| P02452 | COL1A1 | Collagen type I alpha 1 chain | Extracellular space | 0.30 |
| P02458 | COL2A1 | Collagen type II alpha 1 chain | Extracellular space | 0.17 |
| P02461 | COL3A1 | Collagen type III alpha 1 chain | Extracellular space | 0.30 |
| P08572 | COL4A2 | Collagen type IV alpha 2 chain | Extracellular space | 0.39 |
| P12109 | COL6A1 | Collagen type VI alpha 1 chain | Extracellular space | 0.40 |
| P12110 | COL6A2 | Collagen type VI alpha 2 chain | Extracellular space | 0.44 |
| A6NMZ7 | COL6A6 | Collagen type VI alpha 6 chain | Extracellular space | 0.40 |
| P27658 | COL8A1 | Collagen type VIII alpha 1 chain | Extracellular space | 0.33 |
| P48061 | CXCL12 | C-X-C motif chemokine ligand 12 | Extracellular space | 0.35 |
| Q13268 | DHRS2 | Dehydrogenase/reductase 2 | Nucleus | 0.39 |
| P25685 | DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1 | Nucleus | 0.59 |
| Q13217 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 | Cytoplasm | 1.62 |
| Q9NTX5 | ECHDC1 | Ethylmalonyl-CoA decarboxylase 1 | Cytoplasm | 1.69 |
| P30084 | ECHS1 | Enoyl-CoA hydratase, short chain 1 | Cytoplasm | 1.52 |
| P42126 | ECI1 | Enoyl-CoA delta isomerase 1 | Cytoplasm | 1.64 |
| Q08426 | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase | Cytoplasm | 1.62 |
| O15371 | EIF3D | Eukaryotic translation initiation factor 3 subunit D | Cytoplasm | 0.64 |
| P60228 | EIF3E | Eukaryotic translation initiation factor 3 subunit E | Cytoplasm | 0.65 |
| Q13347 | EIF3I | Eukaryotic translation initiation factor 3 subunit I | Cytoplasm | 0.65 |
| P30040 | ERP29 | Endoplasmic reticulum protein 29 | Cytoplasm | 1.81 |
| Q96RP9 | GFM1 | G elongation factor mitochondrial 1 | Cytoplasm | 1.88 |
| P36269 | GGT5 | Gamma-glutamyltransferase 5 | Plasma membrane | 0.57 |
| P23378 | GLDC | Glycine decarboxylase | Cytoplasm | 2.24 |
| P63096 | GNAI1 | G protein subunit alpha i1 | Plasma membrane | 0.48 |
| Q9HAV0 | GNB4 | G protein subunit beta 4 | Plasma membrane | 0.56 |
| Q96SL4 | GPX7 | Glutathione peroxidase 7 | Cytoplasm | 1.66 |
| Q9Y2Q3 | GSTK1 | Glutathione S-transferase kappa 1 | Cytoplasm | 2.13 |
| P09488 | GSTM1 | Glutathione S-transferase mu 1 | Cytoplasm | 0.46 |
| P28161 | GSTM2 | Glutathione S-transferase mu 2 | Cytoplasm | 0.49 |
| B4E2J2 | GSTM3 | Glutathione S-transferase mu 3 | Cytoplasm | 0.37 |
| P46439 | GSTM5 | Glutathione S-transferase mu 5 | Cytoplasm | 0.59 |
| P07305 | H1F0 | H1 histone family member 0 | Nucleus | 0.32 |
| Q92522 | H1FX | H1 histone family member X | Nucleus | 0.34 |
| P16104 | H2AFX | H2A histone family member X | Nucleus | 0.33 |
| O75367 | H2AFY | H2A histone family member Y | Nucleus | 0.47 |
| P0C0S5 | H2AFZ | H2A histone family member Z | Nucleus | 0.25 |
| Q9NRV9 | HEBP1 | Heme binding protein 1 | Cytoplasm | 0.62 |
| Q6NVY1 | HIBCH | 3-Hydroxyisobutyryl-CoA hydrolase | Cytoplasm | 1.58 |
| P16403 | HIST1H1C | Histone cluster 1 H1 family member c | Nucleus | 0.51 |
| P10412 | HIST1H1E | Histone cluster 1 H1 family member e | Nucleus | 0.34 |
| Q96KK5 | HIST1H2AH | Histone cluster 1 H2A family member h | Nucleus | 0.61 |
| P06899 | HIST1H2BJ | Histone cluster 1 H2B family member j | Nucleus | 0.31 |
| O60814 | HIST1H2BK | Histone cluster 1 H2B family member k | Nucleus | 0.52 |
| Q8IUE6 | HIST2H2AB | Histone cluster 2 H2A family member b | Nucleus | 0.22 |
| P28845 | HSD11B1 | Hydroxysteroid 11-beta dehydrogenase 1 | Cytoplasm | 0.52 |
| P11021 | HSPA5 | Heat shock protein family A (Hsp70) member 5 | Cytoplasm | 1.77 |
| P61604 | HSPE1 | Heat shock protein family E (Hsp10) member 1 | Cytoplasm | 1.86 |
| Q9Y4L1 | HYOU1 | Hypoxia upregulated 1 | Cytoplasm | 1.73 |
| Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | Cytoplasm | 0.59 |
| P51884 | LUM | Lumican | Extracellular space | 0.45 |
| Q8IXM3 | MRPL41 | Mitochondrial ribosomal protein L41 | Cytoplasm | 1.53 |
| Q9H2W6 | MRPL46 | Mitochondrial ribosomal protein L46 | Cytoplasm | 1.53 |
| Q13405 | MRPL49 | Mitochondrial ribosomal protein L49 | Cytoplasm | 1.56 |
| Q4U2R6 | MRPL51 | Mitochondrial ribosomal protein L51 | Cytoplasm | 1.57 |
| Q96EL3 | MRPL53 | Mitochondrial ribosomal protein L53 | Cytoplasm | 1.55 |
| Q6P161 | MRPL54 | Mitochondrial ribosomal protein L54 | Cytoplasm | 1.79 |
| O15235 | MRPS12 | Mitochondrial ribosomal protein S12 | Cytoplasm | 2.27 |
| P82914 | MRPS15 | Mitochondrial ribosomal protein S15 | Cytoplasm | 1.50 |
| Q9Y3D9 | MRPS23 | Mitochondrial ribosomal protein S23 | Cytoplasm | 1.78 |
| P82932 | MRPS6 | Mitochondrial ribosomal protein S6 | Cytoplasm | 2.59 |
| P82933 | MRPS9 | Mitochondrial ribosomal protein S9 | Cytoplasm | 1.63 |
| P46199 | MTIF2 | Mitochondrial translational initiation factor 2 | Cytoplasm | 1.55 |
| P20774 | OGN | Osteoglycin | Extracellular space | 0.47 |
| P07237 | P4HB | Prolyl 4-hydroxylase subunit beta | Cytoplasm | 1.56 |
| Q14554 | PDIA5 | Protein disulfide isomerase family A member 5 | Cytoplasm | 1.51 |
| Q9BY49 | PECR | Peroxisomal trans-2-enoyl-CoA reductase | Cytoplasm | 1.57 |
| Q13162 | PRDX4 | Peroxiredoxin 4 | Cytoplasm | 1.64 |
| P51888 | PRELP | Proline and arginine rich end leucine rich repeat protein | Extracellular space | 0.34 |
| P17612 | PRKACA | Protein kinase cAMP-activated catalytic subunit alpha | Cytoplasm | 0.57 |
| P22694 | PRKACB | Protein kinase cAMP-activated catalytic subunit beta | Cytoplasm | 0.50 |
| Q8IZV5 | RDH10 | Retinol dehydrogenase 10 | Nucleus | 2.05 |
| P30050 | RPL12 | Ribosomal protein L12 | Nucleus | 0.57 |
| P62750 | RPL23A | Ribosomal protein L23a | Cytoplasm | 0.65 |
| P32969 | RPL9 | Ribosomal protein L9 | Nucleus | 0.64 |
| P39019 | RPS19 | Ribosomal protein S19 | Cytoplasm | 0.56 |
| P60866 | RPS20 | Ribosomal protein S20 | Cytoplasm | 0.64 |
| P23396 | RPS3 | Ribosomal protein S3 | Cytoplasm | 0.62 |
| P10301 | RRAS | RAS related | Cytoplasm | 0.64 |
| P62070 | RRAS2 | RAS related 2 | Plasma membrane | 0.66 |
| P60468 | SEC61B | Sec61 translocon beta subunit | Cytoplasm | 2.11 |
| Q9Y5M8 | SRPRB | SRP receptor beta subunit | Cytoplasm | 1.55 |
| P37837 | TALDO1 | Transaldolase 1 | Cytoplasm | 0.66 |
| P43897 | TSFM | Ts translation elongation factor, mitochondrial | Cytoplasm | 1.62 |
| P49411 | TUFM | Tu translation elongation factor, mitochondrial | Cytoplasm | 1.52 |
| O95881 | TXNDC12 | Thioredoxin domain containing 12 | Cytoplasm | 1.93 |
| Q99536 | VAT1 | Vesicle amine transport 1 | Plasma membrane | 0.64 |
| P12956 | XRCC6 | X-ray repair cross complementing 6 | Nucleus | 0.59 |