Fig. 2.

Progression free survival according to the presence/absence of alterations in a METAGENE composed of any of the following alterations in the PI3K pathway and/or in Enzymes involved in Epigenetic Signaling. The list of genes included in this analysis was predominantly (but not exclusively) oncogenes from the Tyrosine Kinase receptor/PI3K pathway: PI3KCA and PI3KCB mutations as well as PTEN in association with the following (predominantly suppressor) genes with loss of function alterations in Epigenetic enzymes: KMT2C, KMT2D, KMT2A, KDM5C, EP300, CREBBP, ARID1A, ARID2, ATRX.