Table 2.
PFS according to clinical and tumour characteristics.
|
Univariate |
Multivariate |
|||||
|---|---|---|---|---|---|---|
| HR | IC95%(HR) | p-value | HR | IC95%(HR) | p-value | |
| Age | 0·47 | |||||
| <50 | 1 | |||||
| ≥50 | 1·14 | [0·79; 1·65] | ||||
| Tobacco consumption | 0·62 | |||||
| Never | 1 | |||||
| Yes. current or past (>1PA) | 0·91 | [0·63; 1·31] | ||||
| BMI | 0·01 | 0·03 | ||||
| <25 | 1 | 1 | ||||
| ≥25 | 0·63 | [0·43; 0·91] | 0·66 | [0·45; 0·96] | ||
| ECOG | 0·002 | 0·04 | ||||
| 0 | 1 | 1 | ||||
| 1–2 | 2·10 | [1·32; 3·28] | 1·70 | [1·04; 2·77] | ||
| Histological type | 0·73 | |||||
| Squamous cell carcinoma | 1 | |||||
| Adenocarcinoma | 1·11 | [0·65; 1·88] | ||||
| Adenosquamous. clear cell. mixed + undifferentiated | 0·75 | [0·30; 1·84] | ||||
| Hemoglobin (g/dl) | 0·06 | 0·34 | ||||
| ≤10 | 1 | 1 | ||||
| >10 | 0·61 | [0·37; 1·01] | 0·76 | [0·44; 1·32] | ||
| FIGO 2014 | <0·001 | |||||
| I | 1 | |||||
| II | 1·87 | [1·09; 3·22] | ||||
| III | 4·90 | [2·66; 9·02] | ||||
| IV | 3·64 | [1·83; 7·21] | ||||
| FIGO 2018 (integrates lymph nodes status under IIIC) | <0·001 | 0·004 | ||||
| I | 1 | 1 | ||||
| II | 2·14 | [0·86; 5·35] | 1·83 | [0·72; 4·63] | ||
| III | 4·04 | [1·76; 9·29] | 3·25 | [1·40; 7·57] | ||
| IV | 5·71 | [2·23; 14·60] | 3·46 | [1·28; 9·31] | ||
| HPV type (based on hybridisation test) | 0·17 | 0·56 | ||||
| Clade 9 (HPV 16.31.33.35.52.58) | 1 | 1 | ||||
| Clade 7 (HPV 18.39.45.59.68) | 1·47 | [0·96;2·24] | 1·32 | [0·85; 2·05] | ||
| Others or Negatives | 1·38 | [0·76; 2·52] | 1·30 | [0·69; 2·44] | ||