Figure 5.

Accumulation of Geographic Differences in Random Polygenic Scores

The absolute value of PS difference between western and eastern subpopulations with different numbers of independent variants (r² < 0.1) randomly chosen with GWAS p value > 0.5. For BMI and WHR, the data did not contain more than 60,000 independent variants. The solid region is the 95% probability interval under the theoretical null assumption of zero effect sizes and completely independent variants (r² = 0) (see Material and Methods). Points show the mean, and error bars show the range over ten random scores.