Table 2.
Results from the Linear Model for Correlated Data where Polygenic Score is Explained by Latitude or Longitude
| Latitude | Longitude | |||||
|---|---|---|---|---|---|---|
| Trait | SNPs | Estimate | P value | Estimate | P value | WF-EF Difference (95% CI) |
| CAD | 19,597 | −6.3 × 10−4 | 0.97 | 0.05 | 1.6 × 10−4∗ | −0.63 (−0.71, −0.55) |
| RA | 32,736 | 0.03 | 0.12 | 0.06 | 5.5 × 10−5∗ | −0.63 (−0.71, −0.55) |
| CD | 21,771 | 0.03 | 0.18 | −0.002 | 0.87 | 0.10 (0.01, 0.19) |
| UC | 23,513 | 0.03 | 0.23 | 0.02 | 0.22 | −0.26 (−0.35, −0.18) |
| SCZ | 30,311 | 0.04 | 8.7 × 10−2 | 0.04 | 4.0 × 10−3∗ | −0.35 (−0.43, −0.26) |
| BMI | 12,742 | 0.03 | 9.4 × 10−2 | 0.04 | 1.8 × 10−3∗ | −0.53 (−0.61, −0.44) |
| WHR | 13,727 | 0.10 | 1.0 × 10−9∗ | 0.08 | 4.7 × 10−12∗ | −1.16 (−1.23, −1.09) |
| HG | 27,066 | −0.18 | 1.1 × 10−40∗ | −0.15 | 2.1 × 10−60∗ | 1.51 (1.45, 1.58) |
SNPs = number of variants in PS. The difference in PS between Western Finland (WF) and Eastern Finland (EF) subpopulations is given in the standard deviation unit of PS. ∗ marks a p value < 0.05. Abbreviations are as follows: CI = confidence interval, CAD = coronary artery disease; RA = rheumatoid arthritis; CD = Crohn disease; UC = ulcerative colitis; SCZ = schizophrenia; WHR = waist-hip ratio; BMI = body-mass index; and HG = height.