Table 3.
Summary of the Results in the HG-PS Comparison
| Source GWAS | Ancestry | GWAS N | Finnish Samples | Variants in PS | Adjusted R2 | Predicted WF-EF HG Difference (cm; 95% CI) | Observed WF-EF HG-PS Difference (SD unit; 95% CI) |
|---|---|---|---|---|---|---|---|
| GIANT | European | 253,288 | ∼23,000 | 27,066 | 14% | 3.52 (3.14, 3.90) | 1.51 (1.45, 1.5) |
| GIANT NOFINNS | European | 230,794 | 0 | 25,660 | 17% | 1.78 (1.53, 2.05) | 0.70 (0.62, 0.79) |
| UK Biobank | British | 337,199 | 0 | 113,079 | 22% | 0.64 (0.39, 0.89) | 0.23 (0.14, 0.32) |
| FINRISK | Finnish | 24,919 | 24,919 | 50,536 | 15% | 1.35 (1.14, 1.58) | 0.59 (0.51, 0.67) |
Adjusted R2 is the variance explained by the PS in the target set.