Table 1.

Summary of IgE antibody-mediated effects on human macrophage phenotypes

List of soluble mediators released, gene expression and kinase phosphorylation modifications engendered on human macrophage subsets upon IgE crosslinking. Quiescent M0 and M2 macrophages cross-linked with IgE antibodies acquire typical M1 marker features and are skewed towards a new polarisation status (yellow macrophage). IgE cross-linking on M1 macrophages retains a pro-inflammatory, anti-tumour polarisation status. The five most perturbed kinases amongst 43 analysed were reported in this table. The red arrow indicates increase/decrease of release, expression or phosphorylation level compared to baseline conditions.