Table 1.
Prevalence of CSF positive a‐syn RT‐QuIC test, lag‐phase and final fluorescence values in IPD, LRRK2‐PD, LRRK2‐NMC, and healthy controls
| Subject group (n) | Positive RT‐QuIC [% (n)] | Lag‐phase in positive RT‐QuIC (hours)b | Final fluorescence in positive RT‐QuIC (rfua)b |
|---|---|---|---|
| IPD (10) | 90 (9) | 132 ± 20 | 60955 ± 7685 |
| LRRK2‐PD (15) | 40 (6) | 151 ± 33 | 50402 ± 13862 |
| LRRK2‐NMC (16) | 18.8 (3) | 125 ± 51 | 41228 ± 21852 |
| HC (10) | 20 (2) | 120 ± 40 | 49016 ± 17578 |
CSF, cerebrospinal fluid. IPD, idiopathic Parkinson's disease. LRRK2‐PD, Leucine‐rich repeat kinase 2 Parkinson's disease; LRRK2‐NMC, Leucine‐rich repeat kinase 2 nonmanifesting carriers; HC, Healthy controls.
a
rfu, relative fluorescence unit.
b
Mean ± SD.