Table 2.

Nonmotor symptoms of LRRK2 Parkinson's disease patients

Sex	Positive RT‐QuIC						Negative RT‐QuIC
	M	M	M	M	M	M	F	F	M	F	F	F	F	M	F
Age	51	38	51	59	50	64	45	44	55	68	68	57	48	64	60
Cognitive impairmenta	1	0	1	0	0	1	1	0	0	1	0	0	0	0	0
Depressiona	2	0	1	0	3	1	4	0	0	0	0	0	0	1	1
Urinary problemsa	0	0	0	1	1	1	0	0	0	1	0	0	0	0	0
Constipation problemsa	2	0	1	0	0	1	2	0	0	0	1	0	1	0	3
REM sleep behavior disorderb	No	No	No	No	No	Yes	No	No	No	No	No	No	Yes	No	No
Hyposmiac	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes

MDS, International Parkinson's disease and Movement Disorders Society.

^aInternational Parkinson's disease and Movement Disorders Society Unified Parkinson's Disease Rating Scale part I scores: 0 = normal; 1 = slight, 2 = mild, 3 = moderate, 4 = severe (Goetz et al. 2008).

^bBased on the REM sleep behavior questionnaire (Stiasny‐Kolster et al. 2007).

^cBased on the University of Pennsylvania Smell Test normative values (Doty et al. 1995).