Table 3.

Clinical characteristics and MDS prodromal criteria likelihood ratio of LRRK2 nonmanifesting carriers

Sex	Positive RT‐QuIC			Negative RT‐QuIC
	M	F	M	M	M	M	F	M	M	F	M	M	F	F	M	M
Age	64	47	52	40	64	38	61	27	71	60	28	37	43	51	68	72
Cognitive impairmenta	0	2	0	0	0	0	0	0	0	0	0	0	0	1	0	0
Depressiona	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	0
Bladder symptomsa	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0
Constipationa	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0
RBDb	No	No	No	No	No	No	No	No	No	No	No	No	No	Yes	Yes	No
Hyposmiac	Yes	No	Yes	No	No	No	No	Yes	No	Yes	No	No	No	No	Yes	No
Abnormal DaT‐SPECT	Yes	No	Yes	Yes	No	No	No	No	Yes	No	No	No	No	No	No	No
Meets criteria for prodromal PDd	Yes	No	Yes	No	No	No	No	No	Yes	No	No	No	No	No	No	No
LR for probable prodromal PD PD†	947.6	2.9	1076.8	127.3	2.3	2.9	1.3	29.5	289.3	16.2	0.74	0.74	9.2	5.42	174.7	5.2

RBD, REM sleep behavior disorder; MDS, International Parkinson's disease and Movement Disorders Society; PD, Parkinson's disease; LR, likelihood ratio.

^aInternational Parkinson's disease and Movement Disorders Society Unified Parkinson's Disease Rating Scale part I scores: 0 = normal; 1 = slight, 2 = mild, 3 = moderate, 4 = severe (Goetz et al. 2008).

^bBased on the REM sleep behavior questionnaire (Stiasny‐Kolster et al. 2007).

^cBased on the University of Pennsylvania Smell Test normative values (Doty et al. 1995).

^dThe subject meets the probability threshold of >80% for probable prodromal PD based on the MDS research criteria for prodromal PD (Berg et al. 2015, Mirelman et al. 2018).

^†Total likelihood ratio based on the MDS Research Criteria for prodromal PD (Berg et al. 2015, Mirelman et al. 2018). Missing values were not imputed (LR = 1).