Figure 4.
(a) Cytotoxicity of NIR-ASM against both cancer (A549 and H460) and normal (HUVECs and IMR90) cells. Cytotoxicity was analyzed by resazurin reduction assay by treating with 10 different concentrations of the NIR-ASM. (b) Animals were monitored for changes in body weight as a surrogate marker for toxicity after administration of 10 mg/Kg of NIR-ASM for 5 days a week for 4 weeks. (c) Lack of host toxicity as indicated by the H&E staining of major organs of mice treated with NIR-ASM compared to vehicle-treated (control) mice.