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. 2019 Jun 12;9:8577. doi: 10.1038/s41598-019-44111-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo real-time fluorescence imaging in Lewis Lung Carcinoma (LLC) bearing BALB/c57 mice after intravenous administration of NIR-ASM (5 mg/kg, 50 µL). (a) time-dependent increase in the fluorescence intensity reaching a maximum at 30 min. (b) NIR-ASM illuminated lungs bearing LLC tumors with the minimal background; representative photograph (i) with markings of the heart (H), liver (Li) and Lungs (Lu) and composite image (ii) with fluorescence. (c) Fluorescent imaging of ex vivo-dissected organs such as the spleen (Sp), Lungs (Lu), Heart (H), Kidneys (Ki), Liver (Li) after administration NIR-ASM at 30 min. (d) In vivo fluorescence imaging of non–tumor-bearing mouse after intravenous administration of NIR-ASM. In vivo imaging performed with IVIS Lumina XR Imaging system using excitation/emission filters of ~500/640 nm. The scale indicates fluorescence intensity in terms of radiant efficiency.