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. 2019 Apr 16;43:138–149. doi: 10.1016/j.ebiom.2019.03.083

Fig. 4.

Fig. 4

Localization of DSB repair proteins and histone H3K27me3 mark to γH2AX tracks in DLBCL cells. A. Karpas-422 (EZH2 GOF DLBCL) cells were micro-irradiated as described in the main text and stained with anti-γH2AX along with anti-Mre11, Rad50 or NBS1. B. Karpas-422 DLBCL cells were micro-irradiated as described in the main text and stained with anti-γH2AX and H3K27me3. A reduction in H3K27me3 is seen following treatment of cells with HDAC1,2 inhibitor (RCY957). C. Karpas-422 DLBCL cells were micro-irradiated and stained with anti-γH2AX and phospho-ATM. No change in phospho-ATM localization was observed following treatment of Karpas-422 cells with HDAC1,2-selective inhibitor (RCY957).