Table 4.
Pathways in which the 255 protein‐coding genes containing miR‐SNPs associated with ped‐MS (P < 0.01) are statistically overrepresented
| Pathway name (PANTHER annotation source) | # Protein‐coding genes in pathway | # Expected in 255 ped‐MS genes | # Found in 255 ped‐MS genes | P‐value (FDR) | Ped‐MS genes in pathway |
|---|---|---|---|---|---|
| Histamine H1 Receptor mediated signaling (PANTHER Pathway) | 43 | 0.58 | 5 | 0.035 | GNG4, PLCB3, PLCG2, PRKCB, PRKCI |
| 5‐HT2 type receptor mediated signaling (PANTHER Pathway) | 66 | 0.86 | 6 | 0.064 | PLCB3, PRKCI, PLCG2, GNG4, PRKCB, SLC18A2 |
| MHC Protein Complex (GO Cellular Component) | 25 | 0.34 | 5 | 0.085 | HLA‐DPB1, HLA‐DQB1, HLA‐DRA, HLA‐A, HLA‐G |
| Integral component of lumenal side of endoplasmic reticulum membrane (GO Cellular Component) | 28 | 0.38 | 5 | 0.046 | HLA‐DPB1, HLA‐DQB1, HLA‐DRA, HLA‐A, HLA‐G |
| Interferon gamma signaling (Reactome Pathway) | 90 | 1.21 | 9 | 0.014 | HLA‐DPB1, TRIM14, HLA‐DQB1, HLA‐DRA, HLA‐A, TRIM26/AFP, TRIM10, HLA‐G, CIITA |
For each pathway, the total number of protein‐coding genes in the pathway is given, followed by the number of those genes expected by chance to be found among the 255 ped‐MS associated protein‐coding genes, the actual number found, the P‐value for statistical overrepresentation (adjusted for multiple hypothesis tests), and the list of ped‐MS associated genes in the pathway.