Figure 6.
Partial Abscopal Response after Local Therapy with LTX-401
(A) Schematic depiction of the abscopal tumor model. Animals were inoculated subcutaneously with 1 × 105 JM1 cells on day 0 followed by intrahepatic inoculation with 1 × 105 JM1 cells on day 6. The subcutaneous tumor was treated with 0.4 mg LTX-401 per injection or sterile 0.9% NaCl (control). (B) Subcutaneous (treated) tumor size at day 21 (tumor endpoint). Intrahepatic (untreated) tumor size at (C) day 18 and (D) day 21. One dot represents one animal. *p < 0.05, **p < 0.01, ***p < 0.001 by Mann-Whitney test.