The box represents the median 25 percentile values, and the vertical bar indicates the minimum and maximum values. The “x” mark indicates the mean value. (a) Lactoferrin level was significantly decreased from BL to 1M (n = 17, Wilcoxon test, p = 0.015) and from BL to 6M (Wilcoxon test, p < 0.001). (b) Alpha-1 antitrypsin level was significantly decreased from BL to 6M (n = 17, Wilcoxon test, p = 0.004). (c) Aspartate aminotransferase level was significantly decreased from BL to 3M (n = 17, Wilcoxon test, p = 0.013) and from BL to 6M (Wilcoxon test, p = 0.006).