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(a) VSCs significantly decreased from BL to 6M (n = 20, Wilcoxon test p = 0.015). The box represents the median 25 percentile values, and the vertical bar indicates the minimum and maximum values. The “x” mark indicates the mean value. (b) Rank of VSCs. normal = 0–250 ppb, mild = 251–600 ppb, moderate = 601–1500 ppb, severe = 1501–3000 ppb: not significant (n = 20, chi-square test).
