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. 2019 May 27;16:192–205. doi: 10.1016/j.isci.2019.05.032

Figure 2.

Figure 2

RNA Sequencing Analyses Reveal Global Transcriptional Changes Induced by the HNF4A Mutation in MODY1-HPPs at D14

(A–C) (A) Analysis of downregulated genes via the KEGG pathway. Heatmap analyses of (B) pancreas-related and (C) liver-related genes that are downregulated with fold change (FC) > 1.5, p < 0.05.

(D) Heatmap analyses of numerous caudal HOX genes involved in hindgut specification that are upregulated with FC > 1.5, p < 0.05. Colors in the heatmap depict gene expression in units of SD from the mean across all samples (upregulation in red, downregulation in blue). Controls indicated as 13A, 13B, 7A, 7B, and 7C; MODY1 indicated as 2, 1A–1C.

(E) qPCR analyses of caudal HOX gene expression in control and MODY1-HPPs.

Data are represented as mean ± SD of n = 3, representative of four independent experiments. *p < 0.05 versus control samples by Student's t test. See also Figure S3 and Table S1.