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. 2019 Apr 29;43:238–252. doi: 10.1016/j.ebiom.2019.04.041

Supplementary Fig. S4.

Supplementary Fig. S4

NKX2-8 transcriptionally represses multiple key components of the FAO cascade. a. GO enrichment analysis of the NKX2-8 regulated-transcripts identified in a published gene-set (GSE66957). b. Relative mRNA expression of CPT1A and CPT2 level in the indicated adipocyte-CM-treated EOC cells. Each bar represents the mean ± SD of three independent experiments, ⁎P < 0.05. c-d. Immunoblotting analysis of CPT1A and CPT2 in the indicated adipocyte-CM-treated EOC cells. α-Tubulin served as a loading control. e. Kaplan-Meier survival analysis of the association between CPT1A and CPT2 expression and shorter relapse-free survival in CDDP-treated EOC patients (P < 0.01; n = 144). f. Relative mRNA expression of CPT1A and CPT2 level in public accessed EOC dataset (GSE38666, n = 30; GSE18520, n = 63). g. Kaplan-Meier survival analysis of the association between CPT1A or CPT2 expression and overall survival, shorter relapse-free survival in EOC patients with platinum-based chemotherapy (GSE15622, n = 20).