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. 2019 Jun 6;10:693. doi: 10.3389/fphys.2019.00693

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Copyright © 2019 Karey, Pan, Morris, Bruun, Lein and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Group data of sensitivity and specificity in mice (n = 3) and rats (n = 3). (A) Accuracy of sensitivity (circles) and specificity (squares) at different % change cutoff values (left) and SD cutoff values (right). For % change, the sensitivity and specificity curves intersect at 10–20% change. For SD exclusion method, the sensitivity and specificity curves intersect at ∼1 SD. (B) Group data of four cutoff values (exclusion criteria) in mice: 15%, 20%, 1.5 SD, and 2 SD showing that 1.5 SD exclusion criterion had the lowest sensitivity. 15 and 20% had significantly higher specificity than 1.5 SD and 2 SD criteria. (C) Group data of four cutoff values in rats showing that 15 and 20% had significantly higher specificity than the 1.5 SD and 2 SD criteria. Horizontal bars represent significant difference (p < 0.05) between the two groups.