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. 2018 Jul 15;26(11):3016–3020. doi: 10.1016/j.bmc.2018.05.011

Table 1.

Summary of compounds with improved binding.

Compound Structure ClogPa IC50 (μM)b
NMR154 graphic file with name fx2.gif 2.60 900
2 graphic file with name fx3.gif 3.49 150
3 graphic file with name fx4.gif 4.60 205
4 graphic file with name fx5.gif 3.86 208
5 graphic file with name fx6.gif 3.19 493
6 graphic file with name fx7.gif 2.91 3000
7, CAM187 graphic file with name fx8.gif 3.45 44
a

Calculated of partition coefficient.

b

Half maximal inhibitory concentration.