Table 2.
Rate and risk of outcome events according to number (burden) and anatomical distribution of baseline cerebral microbleeds in all patients (n=20 322)
|
Composite of intracranial haemorrhage and ischaemic stroke (n=19 816 for multivariable model) |
Symptomatic intracranial haemorrhage (n=16 447 for multivariable model) |
Symptomatic ischaemic stroke (n=16 464 for multivariable model) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Rate, per 1000 patient-years* | Absolute rate increase, per 1000 patient-years | Adjusted hazard ratio | Rate, per 1000 patient-years | Absolute rate increase, per 1000 patient-years | Adjusted hazard ratio | Rate, per 1000 patient-years | Absolute rate increase, per 1000 patient-years | Adjusted hazard ratio | ||
| None | 35 (33–38) | .. | 1 (ref) | 4 (3–5) | .. | 1 (ref) | 30 (28–33) | .. | 1 (ref) | |
| Any | 59 (54–64) | 24 (21–26) | 1·35 (1·20–1·50) | 12 (10–14) | 8 (7–9) | 2·45 (1·82–3·29) | 46 (42–51) | 16 (14–18) | 1·23 (1·08–1·40) | |
| One | 46 (40–53) | 11 (7–15) | 1·21 (1·03–1·42) | 8 (5–12) | 4 (2–7) | 1·87 (1·23–2·84) | 37 (31–44) | 7 (3–11) | 1·14 (0·94–1·37) | |
| Number | ||||||||||
| Two to four | 58 (50–67) | 23 (17–29) | 1·25 (1·06–1·47) | 9 (6–14) | 5 (3–9) | 1·89 (1·22–2·93) | 48 (40–56) | 18 (12–23) | 1·17 (0·97–1·42) | |
| Five or more† | 85 (73–99) | 50 (40–61) | 1·74 (1·46–2·06) | 23 (16–31) | 19 (13–26) | 4·55 (3·08–6·72) | 64 (53–77) | 34 (25–43) | 1·47 (1·19–1·80) | |
| Ten or more† | 91 (73–113) | 56 (40–75) | 1·82 (1·44–2·29) | 27 (17–41) | 23 (14–36) | 5·52 (3·36–9·05) | 64 (48–84) | 34 (20–51) | 1·43 (1·07–1·91) | |
| 20 or more† | 118 (86–160) | 83 (53–122) | 2·61 (1·90–3·57) | 39 (21–67) | 35 (18–62) | 8·61 (4·69–15·81) | 73 (46–108) | 43 (18–75) | 1·86 (1·23–2·82) | |
| Anatomical distribution | ||||||||||
| Mixed | 80 (68–94) | 45 (35–56) | 1·28 (1·06–1·54) | 20 (14–28) | 16 (11–23) | 2·38 (1·55–3·65) | 60 (49–73) | 30 (21–40) | 1·12 (0·88–1·41) | |
| Deep | 73 (65–82) | 38 (32–44) | 1·29 (1·12–1·48) | 17 (13–22) | 13 (10–17) | 2·57 (1·78–3·70) | 57 (49–66) | 27 (21–33) | 1·14 (0·96–1·36) | |
| Lobar | 60 (53–67) | 25 (20–29) | 1·22 (1·06–1·41) | 13 (9–16) | 9 (6–9) | 1·87 (1·29–2·71) | 48 (42–56) | 18 (14–23) | 1·17 (0·99–1·40) | |
| Probable cerebral amyloid angiopathy | 55 (40–73) | 20 (7–35) | 1·21 (0·90–1·64) | 9 (4–18) | 5 (1–13) | 1·29 (0·60–2·77) | 48 (34–66) | 18 (6–33) | 1·31 (0·94–1·83) | |
Ranges in brackets are 95% CIs. Cerebral microbleed location hazard ratios are versus patients without cerebral microbleeds in each location and are adjusted for cerebral microbleed number and our prespecified variables.
*
Number of patients and time at risk are shown in the appendix.
†
Overlapping categories.