Table 1.
Role of GA in tissue biomarker changes.
| Groups | TBARS (nM / mg of protein) | GSH (μg / mg of protein) | Total calcium (ppm/mg of protein) | TNF-α (pg/ mg of protein) |
|---|---|---|---|---|
| Control | 3.96 ± 0.53 | 79.12 ± 1.94 | 3.81 ± 0.79 | 31.67 ± 0.32 |
| GA per se | 3.84 ± 0.71 | 77.93 ± 2.04 | 3.97 ± 0.63 | 32.52 ± 0.61 |
| PT | 9.02 ± 0.51* | 38.61 ± 1.73* | 25.47 ± 0.81* | 77.73 ± 0.58* |
| PT + GA (20) | 5.35 ± 0.29# | 68.04 ± 1.93# | 8.71 ± 0.93# | 42.19 ± 0.47# |
| PT + GA (40) | 4.15 ± 0.93# | 74.19 ± 1.62# | 5.17 ± 0.81# | 34.81 ± 0.39# |
| PT + PreG (5) | 3.99 ± 0.69# | 78.92 ± 1.63# | 3.49 ± 0.72# | 30.92 ± 0.71# |
Digits in parenthesis indicate dose in mg/kg. Data were expressed as mean ± SD, n = 6 mice per group. *p < 0.05 vs control group. #p < 0.05 vs PT control group. Abbreviation: GA, gallic acid, PT, paclitaxel; PreG, pregabalin; TBARS, thiobarbituric acid reactive substances; and GSH, reduced glutathione.