Figure 4.

Functional interaction network of histone modifying enzymes (HMEs). (A) Functional interaction network of HMEs, generated through ReactomeFIViz [45] and colored on the basis of node clustering, which is achieved by optimizing network modularity. (B) HME interaction networks, where red and blue colors indicate up- or down-regulation in the tumors, compared with normal tissues, and node diameters are proportional to RPKM (reads per kilobase million) base mean from DESEQ2 (differential gene expression analysis based on the negative binomial distribution) analysis. BRCA; Breast invasive carcinoma.