Figure 1.

Yorkie interactions with the SWI/SNF complex. (A) Brahma and Yki–Sd interact to drive Drosophila midgut intestinal stem cell (ISC) proliferation. Notably, cotransfection with Hippo results in caspase-mediated proteolysis of Brahma and loss of complex stability. (B) Brahma has also been shown to interact with Yki–Sd at Yki target genes to promote tissue overgrowth in the wing disc and eye. This interaction occurred at the crumbs locus, providing evidence for a feed-forward loop of Crumbs-mediated Yki activation in regulation of tissue growth in Drosophila. (C) In the Drosophila wing imaginal disc, yki overexpression drives tissue overgrowth. This overgrowth phenotype was exacerbated by brahma knockdown, providing evidence for a regulatory role of Brahma in limiting Yki-mediated tissue overgrowth. Spacing of grey dots, representing nucleosomes, represents chromatin compaction.