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. 2019 May 24;8(5):502. doi: 10.3390/cells8050502

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Yorkie/YAP interactions with the histone methyltransferase (HMT) complex. (A) Ncoa6, a component of the Trithorax-related (Trr) H3K4 methyltransferase complex, binds to Yki–Sd and is capable of activating a Hippo response element (HRE) reporter in Drosophila. Ncoa6 interaction with Yki–Sd drives the expression of Yki target genes, inducing tissue growth and H3K4 methylation at these loci. (B) Human NCOA6 interaction with YAP–TEAD drives the expression of YAP target genes, providing evidence for evolutionary conservation between this Yki/YAP–HMT interaction.