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YAP/TAZ/TEAD interactions with the NuRD complex. YAP/TAZ–TEAD bind targets and recruit the NuRD complex to repress target expression. This repression is mediated through dual ATP-dependent chromatin remodeling and histone deacetylase (HDAC)-mediated histone deacetylase functions of the NuRD complex to ultimately reduce chromatin accessibility. YAP/TAZ targets repressed by NuRD recruitment included genes that drive apoptosis and promote senescence.
