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. 2019 Apr 28;11(5):594. doi: 10.3390/cancers11050594

Figure 3.

Figure 3

Impact of extrinsic hypoxia in presence of Hif1α and Hif2α. (A) Cellular catecholamines in PC12 cells in dependence of hypoxia. Presence of Hif1α and Hif2α led to an increase of dopamine within the cells. Three independent experiments (n = 6–9). Mean ± SEM. ANOVA and Bonferroni post hoc test comparison vs. normoxia, * p < 0.05. (B) Hypoxia resulted in a significant up-regulation of Th expression in PC12 cells under extrinsic hypoxia, whereas expression of Ddc and Dbh remained unaffected. Four independent experiments (n = 4). Mean ± SEM. ANOVA and Bonferroni post hoc test comparison vs. normoxia, * p < 0.05. (C) Hypoxia further enhanced phosphorylation of TH at Ser40 investigated by Western blot analysis. Shown is a representative section out of three independent experiments.