Table 1.
Human matrix metalloproteases.
| Name of Class | MMP | Enzyme Name | Substrates |
|---|---|---|---|
| Collagenases | MMP-1 | Collagenase-1 | Collagens (I, II, III, VII and X), proteoglycans, entactin, ovostatin, MMP-2, MMP-9 |
| MMP-8 | Collagenase-2/neutrophil collagenase | Collagens (I, II, III, VII, VIII and X), fibronectin, proteoglycans | |
| MMP-13 | Collagenase-3 | Collagens (I, II, III, VII, VIII and X), tenascin, plasminogen, aggrecan, fibronectin, osteonectin, MMP-9 | |
| MMP-18 | Collagenase-4 | Type I collagen | |
| Gelatinases | MMP-2 | Gelatinase-A | Gelatin, collagen (IV, V, VII VI, IX and X), elastin, fibronectin |
| MMP-9 | Gelatinase-A | Collagens (IV, V, VII, X and XIV), gelatin, entactin, elastin, fibronectin, osteonectin, plasminogen, proteoglycans | |
| Stromelysins | MMP-3 | Stromelysin-1 | Collagens (IV, V and IX), gelatin, aggrecan, laminin, elastin, casein, osteonectin, fibronectin, ovostatin, entactin, plasminogen |
| MMP-10 | Stromelysin2 | Collagens (I, II, IV and V), gelatin, casein, elastin, fibronectin | |
| MMP-11 | Stromelysin2 | Collagens (IV, V, IX and X), laminin, elastin, fibronectin, casein, proteoglycans | |
| MMP-17 | Homology tostromelysin-2 | Pro-MMP2, fibrin/fibrinogen, gelatin | |
| Matrilysins | MMP-7 | Matrilysin | Collagens IV, gelatin, fibronectin, laminin, elastin, casein, transferrin |
| MMP-26 | Matrilysin-2 | Collagen IV, fibronectin, fibrinogen, gelatin, pro-MMP9 | |
| MT-MMP (membrane type-MMP) | MMP-14 | MT1-MMP | Collagens (I, II, III), gelatin, fibronectin, laminin, vitronectin, entactin, pro-MMP2 |
| MMP-15 | MT2-MMP | Fibronectin, gelatine, vitronectin, entactin, laminin, pro-MMP-2 | |
| MMP-16 | MT3-MMP | Collagen III, gelatin, casein, fibronectin, pro- MMP-2 | |
| MMP-17 | MT4-MMP | Pro-MMP2, fibrinogen, gelatin | |
| MMP-24 | MT5-MMP | Fibronectin, pro-MMP2, proteoglycans, gelatin | |
| MMP-25 | MT6-MMP | Pro-MMP2, pro-MMP9, collagen IV, gelatine, fibronectin, Proteinase A | |
| Other enzymes | MMP-12 | Macrophage metalloelastase | Collagen IV, gelatin, elastin, casein, fibronectin, vitronectin, laminin, entactin, fibrin/fibrinogen |
| MMP-19 | RASI-1 | Collagen (I, IV) gelatin, fibronectin, laminin | |
| MMP-20 | Enamelysin | Amelogenin, aggrecan | |
| MMP-21 | |||
| MMP-22 | |||
| MMP-23 | Gelatin | ||
| MMP-28 | Epilysin | ||
| MMP-29 | Unnamed |