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. 2019 May 7;10(5):341. doi: 10.3390/genes10050341

Table 1.

Tonic Immobility (TI) quantitative trait loci (QTL) identified in the main mapping population. Chromosome, position (in cM and chr:bp), additive and dominance effects, lower and upper confidence intervals (CI), as well as covariates used and any epistatic interactions incorporated are provided, as is the total variance explained by each QTL (r-squared) and the nearest genetic marker to the upper and lower C.I. Traits are maximum time spent in tonic immobility (TI maximum d.), average time spent in tonic immobility (TI average d.), time spent in tonic immobility in trial 1 (TI duration 1) and time spent in tonic immobility in trial 2 (TI duration 2).

Trait Chr Position LOD Add ± S.E. Dom ±S.E. Lower CI Upper CI Lower Marker Position (Chr:bp) Upper Marker Position (Chr:bp) Covariates Interaction R 2
TI maximum d. 1 2014 5.8 −19.9 ± 21.6 −25.7± 42.1 1991 2038 1_190334672 1:190334672 1_195271649 1:195271649 sex, batch, PC2,3,10 1@2014.0:2@485.0 3.7
TI duration 2 1 1750 7.3 −30.8 ± 11.7 −2.0 ± 15.4 1735 1756 Gg_rs10728648 1:144081810 snp-23-342-18608-S-2 1:151495059 sex, batch, PC2,6 1@1748.0:7@3.0 5
TI average d. 2 774 6.5 −10.8 ± 9.2 −28.7± 14 764 795 RBL1120 2:116617839 Gg_rs15146557 2:117659953 sex, batch, PC2,6 2@774.0:24@60.7 4.6
TI maximum d. 2 485 7.3 27.9 ± 13.1 −3.3 ± 17 474 495 Gg_rs14190959 2:60361704 Gg_rs15110213 2:65012153 sex, batch, PC2,3,10 1@2014.0:2@485.0 4.7
TI maximum d. 2 775 7.3 −9.9 ± 12.8 −18.1± 19.3 767 798 RBL1120 2:116617839 Gg_rs15146557 2:117659953 sex, batch, PC2,3,10 2@775.0:24@61.0 4.7
TI duration 2 2 181 7.9 −63.0 ± 14.9 −35.7± 18.3 170 195 Gg_rs15070042 2:19473457 2_23979784 2:23979784 sex, batch, PC2,6 24@60.7:2@181.0 5.2
TI duration 1 4 283 9.7 33.4 ± 10.5 11.4 ± 16.2 272 292 Gg_rs14446625 4:31963411 4_37860292 4:37860292 sex, batch, PC1,4 4@283.0:15@187.9 7.8
TI duration 1 6 259 6.9 5.6 ± 9.1 10.7 ± 12.2 247 270 6_25762392 6:25762392 Gg_rs14592224 6:30433595 sex, batch, PC1,4 6@258.7:10@185.0 5.5
TI duration 2 7 4 11.5 11.2 ± 13.5 48.5 ± 17.7 0 8 Gg_rs15826188 7:1654910 Gg_rs15828492 7:2444843 sex, batch, PC2,6 1@1748.0:7@3.0, 7@3.0:24@60.7 7.8
TI average d. 10 99 5.9 −15.1 ± 7.7 14.9 ± 10.1 86 109 Gg_rs14941656 10:2678686 Gg_rs14003134 10:5805005 sex, batch, PC2,6 10@99.0:20@247.7 4.1
TI maximum d. 10 139 8.4 −24 ± 11.4 −35.5 ± 15.1 133 144 10_9525779 10:9525779 Gg_rs14947769 10:11621480 sex, batch, PC2,3,10 10@139.0:12@85.0 5.4
TI duration 1 10 185 8.5 2.4 ± 9.5 −34.6± 12.2 176 198 Gg_rs14008254 10:12705455 GG_rs14951592 10:15605204 sex, batch, PC1,4 6@258.7:10@185.0 6.8
TI maximum d. 12 85 7.2 −24.2 ± 11.5 8.7 ± 14.7 77 190 Gg_rs13609494 12:5140626 12_14051161 12:14051161 sex, batch, PC2,3,10 10@139.0:12@85.0 4.7
TI duration 1 15 188 7.9 −18.0 ± 9.6 −19.5± 12.3 177 189 Gg_rs14095161 15:10467522 Gg_rs14095923 15:11490734 sex, batch, PC1,4 4@283.0:15@187.9 6.3
TI average d. 20 247.7 6.4 −9.4 ± 7.1 24 ± 10.1 237 252 Gg_rs15177950 20:10931547 Gg_rs14280872 20:13367853 sex, batch, PC2,6 10@99.0:20@247.7 4.8
TI average d. 24 60.7 7 −20.9 ± 8.5 −21.0± 11 53 67 GG_rs16194400 24:1782119 Gg_rs14294768 24:3003659 sex, batch, PC2,6 2@774.0:24@60.7 4.9
TI maximum d. 24 61 8.7 −26.6 ± 11.9 −25.0 ± 15.4 54 66 GG_rs16194400 24:1782119 Gg_rs14294768 24:3003659 sex, batch, PC2,3,10 2@775.0:24@61.0 5.6
TI duration 2 24 61 16.5 21.5 ± 15.3 −40.9 ± 18.7 54 65 GG_rs16194400 24:1782119 Gg_rs14294768 24:3003659 sex, batch, PC2,6 7@3.0:24@60.7, 24@60.7:2@181.0 11.5