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Cytotoxicity of 1–11 against MCF-7, MDA-MB-231, and BT-474 cells (IC50, μM).
| Compounds | Cell lines | ||
|---|---|---|---|
| MCF-7 | MDA-MB-231 | BT-474 | |
| 1 | 6.07 ± 0.09 | 7.72 ± 0.76 | 4.27 ± 2.09 |
| 2 | >20 | >20 | >20 |
| 3 | >20 | >20 | >20 |
| 4 | >20 | >20 | >20 |
| 5 | 7.58 ± 1.19 | 8.01 ± 0.55 | 6.46 ± 1.92 |
| 6 | >20 | >20 | >20 |
| 7 | 0.42 ± 0.03 | 0.35 ± 0.03 | 0.67 ± 0.09 |
| 8 | 0.24 ± 0.01 | 0.16 ± 0.02 | 0.28 ± 0.09 |
| 9 | 0.40 ± 0.01 | 0.38 ± 0.04 | 0.41 ± 0.15 |
| 10 | >20 | >20 | >20 |
| 11 | >20 | >20 | >20 |
| Doxorubicin | 0.86 ± 0.64 | 1.30 ± 0.25 | 0.39 ± 0.06 |
