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. 2019 May 5;17(5):265. doi: 10.3390/md17050265

Figure 5.

Figure 5

(A) Analgesic effect of GeXIVA[1,2] on oxaliplatin-induced cold allodynia by single IM injection. Time–effect relationship of GeXIVA[1,2] in acetone stimulation cold score. Each point indicates the mean ± SEM at the time point, (NS, n = 10; GeXIVA[1,2], n = 9 (32 nmol/kg), n = 10, (64 nmol/kg, 128 nmol/kg); Gabapentin 50 mg/kg, n = 8). (B) AUC of corresponding dose within 6 h after injection indicating the dose–effect relationship. * P < 0.05, *** P < 0.001, compared with the NS control group.