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. 2019 May 22;8(5):489. doi: 10.3390/cells8050489

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lessons from IV 3D cultures. trans-urocanic acid (UCA) and pyrrolidone carboxylic acid (PCA) produced by Filaggrin (FLG) proteolysis likely serve as natural sunscreens. Accumulation of 15-HETE in IV epidermis might limit the extent of damage inflicted by UV-irradiation. FLG does not significantly contribute to the acidic pH of skin. FLG deficiency leads to an abnormal, but not completely defective, stratum corneum (SC) and has little or no effect on the keratinocyte (KC) differentiation process.