Table 1.
Summary of the role of YAP and TAZ function in physiological and pathological angiogenesis.
| Main Finding | Ref. |
|---|---|
| Angiomotin is a negative regulator of YAP | [44] |
| Angiomotin-like 1 degradation by Nedd4 is regulated by YAP through c-ABL | [60] |
| YAP/TAZ are the main mediators of mechanotransduction in endothelial cells | [72] |
| BMP9 crosstalk with the Hippo pathway regulates endothelial cell matricellular response | [80] |
| mRNAs upregulated in ECs in response to TGFβ1 treatment are involved in hippo signaling | [81] |
| Flow-dependent endothelial YAP regulation contributes to vessel maintenance | [73] |
| YAP/TAZ negatively regulate prox1 during developmental and pathologic lymphangiogenesis | [92] |
| YAP disruption in mice causes defects in yolk sac vasculogenesis and chorioallantoic fusion | [94] |
| YAP/TAZ activity is essential for vascular regression via Ctgf and actin polymerization | [95] |
| Adherens junction and endothelial cell distribution in angiogenesis is regulated by YAP/TAZ | [100] |
| YAP regulates angiopoietin-2 expression in ECs | [101] |
| Vascular tip cell migration is regulated by YAP/TAZ-CDC42 signaling pathway | [102] |
| VEGFR is a regulator of YAP/TAZ in the Hippo pathway in angiogenesis through PI3K/MAPK pathways | [106] |
| VEGF activates YAP/TAZ via its effects on actin cytoskeleton | [107] |
| YAP promotes angiogenesis via Stat3 | [108] |
| YAP mediates angiotensin II-induced vascular smooth muscle cell phenotypic modulation and hypertensive vascular remodelling | [115] |
| YAP inhibition ameliorates choroidal neovascularization | [117] |
| YAP/TAZ regulates vascular barrier maturation | [118] |
| YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in retina | [119] |
| Substance P accelerates wound healing in type 2 diabetic mice through YAP activation | [121] |
| Ultrasound treatment accelerates angiogenesis by activating YAP/TAZ | [122] |
| Palmitic acid inhibits angiogenesis through YAP suppression | [123] |
| YAP1-TEAD1 controls angiogenesis and mitochondrial biogenesis through PGC1α. | [124] |
| Blood vascular density and VEGFR2 expression in astrocytomas is regulated by TAZ | [126] |
| Cell proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma is regulated by YAP | [128] |
| YAP regulates OCT4 activity and SOX2 expression to facilitate vascular mimicry | [142] |
| Verteporfin suppresses vasculogenic mimicry of pancreatic ductal adenocarcinoma | [143] |