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. 2019 May 24;17(5):306. doi: 10.3390/md17050306

Figure 7.

Figure 7

PnTX-A (84 nM) and PnTX-G (54 nM) block full-sized EPPs evoked by nerve stimulation, while 100 nM PnTX-AK (containing an open form of the imine ring) had no action on EPP amplitudes. (a) Representative control EPP recorded in a junction from an EDL muscle that has been treated with µ-conotoxin GIIIB to prevent muscle action potentials generation. (b) EPP recorded during the action of PnTX-G (20 nM). (c) Full-sized EPP recorded after 30 min of 100 nM PnTX-AK. (d) Graphs showing control EPP values (mean ± SEM; n = 4–8 for each condition), the significant (*: P < 0.05) reduction of EPP amplitudes by PnTX-A and G, and the lack of action of PnTX-AK (100 nM).