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Drug-like properties of Oxy186. (a) A single dose of Oxy186 at 50 mg/kg, formulated in 4% ethanol/ 15% DMSO/ 81% corn oil, was administered to balb/c mice by oral gavage. Plasma samples were taken at 10 min, 30 min, 1, 2, 4, 6, 8, and 24 h, followed by LC/MS analysis of the plasma. (b) Evolution of Oxy186 from parent compound Oxy16 and their drug-like properties.
