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Steps of TNF-related apoptosis-inducing ligand (TRAIL) sensitization in melanoma. The interplay of extrinsic and intrinsic apoptosis pathways for TRAIL signaling in melanoma cells is shown. Important steps are the activation of Bax and the release of Smac. Further explanations are given in the text. Abbreviations: CM, cytoplasma membrane; DISC, death-inducing signaling complex.
